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Excellent Product! Felt the beneficial effects 3 weeks after starting it. Also Excellent After Sale Service. Experienced some issues when ordering product but was swiftly resolved with minimal fuss!
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PATENTED NCK2025™ STRAIN
CodonRX | AI High Potency Probiotic Capsules for Dietary Management of Digestive and Gut Health
Lactobacillus acidophilus NCK2025™ — precision-engineered, LTA-free
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CodonRX | AI High Potency Probiotic Capsules for Dietary Management of Digestive and Gut Health
What's in the carton
- 60 capsules (30-day supply)
- 20 billion CFU NCK2025™
- LTA-free · No inflammatory trigger
- 2 capsules once daily
- Vegan · allergen-free
- No dairy, gluten, soy, or nuts
- Refrigerate after opening
- Made in the USA
Peer-reviewed research
Patented Technology
Proudly made in the USA
Vegan & allergen-free
The CodonRX Difference
Engineered for people failed by other probiotics
Standard probiotics were designed for general wellness. CodonRX® was designed specifically for people with IBS and underlying gut sensitivity.
Precision-Engineered to be LTA-Free
Standard probiotics carry LTA — a surface molecule shown to compound existing gut inflammation.1 NCK2025™ is precision-engineered without LTA.
Single-Strain Efficacy
Multi-strain probiotics introduce more LTA, compounding existing inflammation. CodonRX® is a single, high-performance product shown to rebalance gut inflammation.2
40+ Years of University Research
CodonRX® is the product of decades of research at North Carolina State University, published in peer-reviewed journals, and protected by two U.S. patents.
How It Works
Three steps. One result.
01
Eliminating the Trigger
NCK2025™ delivers all the colonization benefit of standard L. acidophilus — minus the LTA molecule that signals inflammation. You get gut support without the gut stress.
02
Single-Strain Potency
One strain, rigorously studied, precisely dosed at 20 billion CFU. No guesswork, no filler. Just the strain with 40+ years of documented research behind it.
03
Targeted Restoration
Daily use helps restore a balanced microbiome — supporting regularity, reducing bloating, and building long-term digestive resilience over 30–60 days of consistent use.
Supplement Facts
What's inside every capsule
Why packaging matters
Individually sealed for maximum potency
Most probiotic bottles expose contents to air and humidity every time you open them. CodonRX® is individually sealed to protect each capsule from humidity, oxygen, and environmental contaminants.
- Each capsule sealed at the point of manufacture
- Moisture and oxygen barrier maintained until use
- Keeps each capsule contaminant and allergen-free
Active Ingredient
Lactobacillus acidophilus NCK2025™
20BCFU per serving
CodonRX® is the only patented, LTA-free strain probiotic on the market. It delivers all the benefits of a premium probiotic — without the pro-inflammatory trigger that standard strains carry on their surface.
Protected by: U.S. Patents 9,340,792 & 9,980,992
GMP Lab Tested & Allergen-Free
Dairy-free
Egg-free
Soy-free
Shellfish-free
Tree Nut-free
Peanut-free
Fish-free
Wheat-free
Sesame-free
Gluten-free
Vegan
How to Take CodonRX®
- Dose: Take 2 capsules once daily, with or without food.
- Consistency: Take at the same time each day. Gut microbiome changes take time — consistency matters more than timing.
- Storage: Refrigerate after opening to maintain potency. Best before date printed on the carton.
- Timeline: Most customers notice initial improvement within 2–4 weeks. For best results, continue for 60 days.
Supplement Facts
| Serving Size: 2 Capsules | Amount Per Serving |
|---|---|
| L. acidophilus NCK2025™ | 20 Billion CFU* |
* Daily Value not established
Other Ingredients: Hypromellose (capsule), microcrystalline cellulose.
Other Ingredients: Hypromellose (capsule), microcrystalline cellulose.
Peer-reviewed science
NCK2025™ rebalances existing gut inflammation
Published research shows NCK2025™ significantly reduces pro-inflammatory signals in the gut while boosting anti-inflammatory ones — shifting an over-reactive gut to homeostasis.
This is mechanism-driven, peer-reviewed evidence.
References
1 Zadeh M, et al. "Induction of intestinal pro- and anti-inflammatory immune responses by lipoteichoic acid-deficient Lactobacillus acidophilus." Journal of Inflammation. 2012;9:4.
2 Mohamadzadeh M, et al. "Regulation of induced colitis by Lactobacillus acidophilus deficient in lipoteichoic acid." Proc. National Academy of Sciences. 2011;108 Suppl 1:4550–4557.
40+ years of research
Born in the lab. Trusted by the experts.
CodonRX® is built on four decades of probiotic research at NC State University and backed by leaders in gastroenterology and nutritional science.
Scientific Advisory Board
Dr. Rodolphe Barrangou, Ph.D.
Inventor of CRISPR gene-editing technology
Distinguished Professor, Food & Nutritional Sciences · NC State University
Distinguished Professor, Food & Nutritional Sciences · NC State University
Our labs at NC State spent years researching and developing the anti-inflammatory properties of CodonRX. It's rare for patented research to evolve into a real-world product that enhances quality of life. I'm thrilled to see CodonRX reach the market and hopeful that it will make a meaningful difference in consumer's health.
Clinical Endorsement
Dr. George Triadafilopoulos, M.D.
Emeritus Professor · Stanford University
Professor of Gastroenterology & Nutrition · UT MD Anderson Cancer Center
Professor of Gastroenterology & Nutrition · UT MD Anderson Cancer Center
As a long-time practicing gastroenterologist, I am excited to see the availability of novel products, such as CodonRX®, with its unique probiotic properties.
Protected by two U.S. patents — 9,340,792 & 9,980,992 · Licensed from NC State University
What to Expect
Real results take real time.
We'll be straight with you: the microbiome doesn't transform overnight. Here's a realistic timeline based on what our customers actually experience.
1–2
Weeks 1–2
Early Signs
Some customers notice initial improvements in comfort and regularity within the first two weeks. A brief adjustment period — mild gas or bloating — is normal and typically resolves within the first few days.
3–4
Weeks 3–4
Noticeable Shift
"Felt the beneficial effects 3 weeks after starting." This is when most customers report a meaningful change in bloating, gas, and digestive consistency. The NCK2025™ strain is establishing itself.
60
Day 60+
Sustained Relief
"Rarely experienced that discomfort at all." At 60 days of daily use, customers report lasting microbiome balance — the kind of change that doesn't disappear when you skip a day.
Discover what CodonRX can do for you
Patented NCK2025™ — the only LTA-free probiotic. Backed by 40+ years of university research.
Monthly
$85
/carton
Auto-delivery · Cancel anytime
One-time
$85
/carton
No commitment
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. NCK2025™ and CodonRX® are trademarks of CodonRX. U.S. Patents 9,340,792 & 9,980,992. Licensed from NC State University. Individual results may vary.
Before you order
Common questions about your order, subscription, and what to expect.
Take 2 capsules once daily, with or without food. Refrigerate after opening to maintain potency. Each carton contains 60 capsules — a 30-day supply.
Most customers notice initial improvements within 2–4 weeks. For best results, take CodonRX® consistently for 30–60 days. Gut microbiome changes take time to stabilize — consistency matters more than timing.
Each order includes one carton of CodonRX® containing 60 individually foil-sealed capsules — a 30-day supply at the recommended dose of 2 capsules per day. Subscription orders will renew and ship automatically every 30 days - a reminder email will be sent 5 days before each renewal.
Yes. Subscriptions can be cancelled at any time with no fees or penalties. You can manage or cancel your subscription from your account dashboard or by contacting our support team before your next billing date.
We stand behind CodonRX®. If you're unsatisfied with your purchase, contact our support team within 30 days of delivery and we'll make it right. Please reach out before returning any product.
CodonRX® ships Mondays to Wednesdays via standard FedEX 2 day with specialized packaging designed to absorb heat. Rest assured the product is temperature stable. Each capsule is individually foil-sealed for stability in transit. Once received, refrigerate the carton to maintain peak potency through the best-before date printed on the box.
Some customers experience mild, temporary gas or bloating during the first few days as their gut microbiome adjusts. This typically settles within the first week. If symptoms are severe or persist beyond two weeks, discontinue use and consult your healthcare provider.
CodonRX® is vegan, allergen-free, and contains no dairy, gluten, soy, or nuts. As with any supplement, if you are taking prescription medications or have a medical condition, consult your healthcare provider before use.
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