What is CodonRX®?

CodonRX® was created to make high-quality, science-backed health products more affordable and accessible.

Targeted Relief for Digestive Discomfort

CodonRX® | AI (Anti-Inflammatory formulation) is uniquely designed to help relieve chronic digestive symptoms, including diarrhea, bloating, gas, abdominal pain, and constipation. CodonRX® is frequently used by IBS and IBD patients.

Take Control of Your Health with our Free App

The CodonRX app pairs with CodonRX | AI probiotics for a powerful system to manage your gut health. Sign up here for early access to our app.

Backed by Science. Designed for Gut Health.

CodonRX® | AI is the result of decades of groundbreaking microbiome and genome research at North Carolina State University in the legendary food and supplement science labs of Todd Klaenhammer and Rodolphe Barrangou. Our patented probiotic is engineered to target gut inflammation. CodonRX® | AI acts like a traffic signal in your microbiome, helping to reduce pro-inflammatory substances while promoting beneficial, anti-inflammatory compounds.

Our mission is to make this scientifically advanced gut health solution accessible to everyone who can benefit from a healthier gut microbiome.

How does it all work?

Have you tried a probiotic before where you saw some immediate symptoms relieved, only to have the symptoms return or worsen a few days or weeks later?

Well, we can explain that.

You see, all probiotics have the same compound on its exterior. This compound is a fatty acid chain and is called Lipoteochoic Acid (LTA). This compound has been shown in studies to cause inflammation in the large and small intestines.

The active ingredient behind CodonRX® is modified with this LTA compound removed is patent protected (USPTO #9,340,792 and #9,980,992). Not only does this mean that the benefits of the probiotic can be delivered safely to the intestines without irritating the gut lining, but this modification has been shown in clinical studies^{1, 2, 3, 4} to serve as a traffic light, capable of signaling the body to reduce the production of pro-inflammatory molecules and produce more anti-inflammatory molecules.

Our exclusive formulation goes beyond balancing gut bacteria—it actively supports a healthier digestive system free from inflammatory molecules found on all other probiotics, helping you feel better from the inside out.

Experience the CodonRX® Difference

At CodonRX®, we believe that scientific breakthroughs should be both effective and accessible. If you’ve struggled with digestive issues and haven’t found relief with other probiotics, it’s time for a new approach.

Take control of your gut health today—try CodonRX® | AI and feel the difference.

1. [1] Mohamadzadeh et al., PNAS 108, 4623-4630 (2011).
2. [2] Zadeh et al., Journal of Inflammation, 9, 1-12 (2012).

1. [3] Khan et al., Immunotherapy, 4, 151-161 (2012).
2. [4] Khashayarsha et al., PNAS 109, 10462-10467 (2012).

Advanced Science

"Nearly 20 years of research at the North Carolina State University Department of Food, Bioprocessing and Nutritional Sciences has gone into the CodonRX | AI product, and I am thrilled that CodonRX is finally making this patented probiotic available to the world. Our team shares in the CodonRX commitment to using the best science and technology to help people improve their health.”

-- Rodolphe Barrangou, Ph.D.
Professor, Department of Food, Bioprocessing and Nutritional Sciences
North Carolina State University

Better Health

“A balanced bacterial ecosystem in the digestive tract is an important key to maintaining our health. Tens of millions of people worldwide, suffer from digestive distress due to unhealthy gut bacteria that lead to inflammation.  As a long-time practicing gastroenterologist and researcher, I am excited to see the availability of novel products, such as CodonRX | AI, with its unique probiotic properties.”